Title : New perspectives in the renin - angiotensin - aldosterone system ( RAAS ) II : albumin suppresses angiotensin converting enzyme ( ACE ) activity in human
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چکیده
Title: New perspectives in the renin-angiotensin-aldosterone system (RAAS) II: albumin suppresses angiotensin converting enzyme (ACE) activity in human Authors: Miklós Fagyas, Katalin Úri; Ivetta M. Siket; Gábor Á. Fülöp; Viktória Csató; Andrea Daragó, Judit Boczán, Emese Bányai, István Elek Szentkirályi, Tamás Miklós Maros, Tamás Szerafin, István Édes, Zoltán Papp, Attila Tóth Affiliations: Division of Clinical Physiology, Institute of Cardiology, University of Debrecen, Debrecen, Hungary Department of Neurology, University of Debrecen, Debrecen, Hungary Institute of Internal Medicine, Division of Nephrology, University of Debrecen, Debrecen, Hungary Department of Cardiac Surgery, Institute of Cardiology, University of Debrecen, Debrecen, Hungary
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The renin-angiotensin-aldosterone system: approaches to cardiac and renal therapy.
The renin-angiotensin-aldosterone system (RAAS) plays a prominent role in the pathophysiology of cardiac and renal diseases. Aldosterone leads to local effects of vasoconstriction, sodium resorption, and possibly inflammation and fibrosis in several organs. Pharmacologic manipulation of the RAAS may involve renin inhibitors, angiotensin-converting enzyme inhibitors, angiotensin II–receptor bloc...
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Hypertension is commonly associated with chronic renal disease in cats, and inappropriate activation of the renin-angiotensin-aldosterone system (RAAS) may contribute to the hypertensive state. Angiotensin-converting enzyme (ACE) inhibitors are commonly administered when hypertension is present to decrease plasma concentrations of angiotensin II and aldosterone, which cause vasoconstriction and...
متن کاملNew Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) II: Albumin Suppresses Angiotensin Converting Enzyme (ACE) Activity in Human
About 8% of the adult population is taking angiotensin-converting enzyme (ACE) inhibitors to treat cardiovascular disease including hypertension, myocardial infarction and heart failure. These drugs decrease mortality by up to one-fifth in these patients. We and others have reported previously that endogenous inhibitory substances suppress serum ACE activity, in vivo, similarly to the ACE inhib...
متن کاملThe renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition.
BACKGROUND The renin-angiotensin aldosterone system (RAAS) is a hormonal cascade that functions in the homeostatic control of arterial pressure, tissue perfusion, and extracellular volume. Dysregulation of the RAAS plays an important role in the pathogenesis of cardiovascular and renal disorders. OBJECTIVES To review the role of the RAAS in the development of hypertensive cardiovascular disea...
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